Immunoprecipitation and mass spectrometry defines an extensive RBM45 protein–protein interaction network
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چکیده
منابع مشابه
Immunoprecipitation and mass spectrometry defines an extensive RBM45 protein–protein interaction network
The pathological accumulation of RNA-binding proteins (RBPs) within inclusion bodies is a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). RBP aggregation results in both toxic gain and loss of normal function. Determining the protein binding partners and normal functions of disease-associated RBPs is necessary to fully understand molecular mechanism...
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In the life sciences, a new paradigm is emerging that places networks of interacting molecules between genotype and phenotype. These networks are dynamically modulated by a multitude of factors, and the properties emerging from the network as a whole determine observable phenotypes. This paradigm is usually referred to as systems biology, network biology, or integrative biology. Mass spectromet...
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Akt is a critical protein for cell survival and known to interact with various proteins. However, Akt binding partners that modulate or regulate Akt activation have not been fully elucidated. Identification of Akt-interacting proteins has been customarily achieved by co-immunoprecipitation combined with western blot and/or MS analysis. An intrinsic problem of the method is loss of interacting p...
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ژورنال
عنوان ژورنال: Brain Research
سال: 2016
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2016.02.047